Despite the normalcy of the world around them, twelve women across Japan could see something nobody else could: a tiny red star nestled closely to the moon. Legends tell of twelve Princesses who traveled to the cursed land of Fuuka to do battle for their dreams three hundred years ago. Now, another twelve girls are being brought to Fuka High School. They are the HiME: Highly-Advanced Materializing Equipment, capable of fusing higher-order matter into Elements and Childs. Without their knowledge, their fates have been planned by shadowy organizations for centuries. The twelve Princesses are returning to the cursed land, and each one is completely unaware of the forces that grasp for them from the shadows.