A modern-day world where humans have a latent potential for psi powers such as telepathy, precognition, telekinesis, pyrokinesis and healing. The powers themselves are extremely rare and usually locked beyond reach. A mysterious being known as Nemesis Q recruits people, sending them into an apocalyptic future to learn about the future destruction of the world in the hopes of preventing the catastrophe. Exposed to this wasteland which somehow makes psi powers vastly stronger, humans become Psyren Drifters, unlocking their latent psi powers. Psyren Drifters attempt to overcome the challenges of this future world and understand what happened to their own world while participating in Nemesis Q's challenge to control the future.